Gamete intrafallopian transfer (GIFT)

What is GIFT?

GIFT is a helped conceptive methodology which includes uprooting a lady's eggs, blending them with sperm, and quickly setting them into a fallopian tube. One of the fundamental contrasts between this strategy and in vitro treatment (IVF) and zygote intrafallopian exchange (ZIFT) methods is that with GIFT the preparation procedure happens inside the fallopian tube instead of in a lab. Nonetheless, sound tubes are vital for GIFT to work.

GIFT is a procedure to augment preparation of the egg inside of the fallopian tubes, the normal site of treatment. The eggs are recovered vaginally, utilizing ultrasound direction, and set into the fallopian tubes with sperm by laparoscopy or laparotomy.

How is GIFT performed?

GIFT is proper for the accompanying sorts of patients:

§      Women with no less than one typical fallopian tube

§      Couples where the spouse has more than two million sperm in his discharge

§      Couples who have an ethical or religious worry with IVF

GIFT is a helped regenerative system that includes the accompanying:

1.      Patients must first have a x-beam to decide the vicinity of no less than one sound fallopian tube. The specialist will likewise utilize a laparoscope to guarantee that there is not any scar tissue on the outside of the fallopian tube.

2.      Using a laparoscope, eggs are then recovered from the ovaries.

3.      The male gives a sperm test that day that the eggs are recovered.

4.      The eggs are then blended with the sperm in a catheter.

5.      The egg and sperm blend is embedded into the fallopian tubes with a catheter.

6.      The lady is then furnished with pharmaceutical to develop the uterine coating to bolster implantation of a treated egg.

7.      Before GIFT can be performed, patients must have no less than one typical fallopian tube recorded by a x-beam (hysterosalpingogram) and the nonappearance of scar tissue in the outside of the tube reported by laparoscopy.

8.      GIFT does not require hospitalization. The lady is in recuperation for around eight hours after the strategy. A potential downside of GIFT is the absence of obvious affirmation of treatment.

In the event that any extra eggs are left over, you may utilize them for IVF and spare any reasonable incipient organisms to use later on.

Who can be treated with GIFT?

GIFT has been utilized with the accompanying patients:

•        Couples with unexplainable barrenness

•        Couples who have not had accomplishment with IVF

•        Couples who have a religious or good hesitance to utilize IVF

•        Women who have no less than one solid fallopian tube

•        Couples in which the spouse has a low sperm tally or different issues with his sperm

Notwithstanding, as indicated by the National Institute for Health and Care Excellence, gamete intrafallopian exchange or zygote intrafallopian move in inclination to IVF in couples with unexplained ripeness issues or male element richness issues."

What are the contrasts in the middle of GIFT and in vitro treatment (IVF)?

•        With IVF, the eggs are prepared in a research facility as opposed to in the fallopian tubes as with GIFT.

•        IVF can be utilized with couples as a part of which the female does not have fallopian tubes or has blocked fallopian tubes.

•        IVF takes into consideration preparation affirmation and evaluation of developing life quality.

•        GIFT does not include treatment outside of the body, so couples don't need to manage the moral worries with picking which devel

CAUSES AND TREATMENT OF MALE INFERTILITY

What causes male infertility?

     Infertility in man is usually caused as a result of production of sperm or its mobility. Medical test by doctor will reveal the main problem associated to the infertility.75% of men infertility is associated with production of sperm.  It’s either the sperm produces are not enough or they are not working effectively.

Transportation of sperm are as a problem are  found in about two third of male , those men that had a vasectomy wish now want  to have more children. Blockages otherwise known as obstructions in tubes which leads to sperm moving from testes to the penis and cause complete absence of sperm in ejaculation of semen.

Less common effect of infertility are: sexual intercourse issues which  affect either semen will  be able to pass through the woman’s vagina for  effective fertilization to occur at least one  in every  100 infertile marriage: decrease in hormones  level made master pituitary gland act on the testes  at least one in every  100 infertility men and sperm antibodies  which occur in one in every  16 infertility men. Most male  antibodies will not hinder the occurrence  of pregnancy  otherwise men sperm antibodies  decrease fertility.

Essential causes of male infertility

Sperm production issues       

• genetic or chromosomal  causes

• testes  undescended

• Infection

• Torsion

• Varicocele

• chemical and medicine

• damage due to radiation

• cause may be unknown

Sperm transport blockage   

• Infection

• Vasectomy

• Absence of vas deferens

• Prostate-related problems

Sexual  Intercourse Issues

• ejaculation failure

• dysfunction of erectile

• intercourse infrequent

• injury of the spinal cord

• surgery of prostrate

• nerves damages

• medicines in take

     Over  80% of male infertility issues are as a result of poor sperm quality and  low sperm counts or both. Remaining issues of male infertility are as a result of a range of conditions which are genetic defects anatomical problems and  hormonal imbalances.

Infertility in male are with many causes—from psychological ,behavioral problems ,hormonal imbalances and to physical problems.  Furthermore , human  fertility reflects its  healthiness.  Those men with healthy lifestyle shows likely to make healthy sperm.  The following shows  few lifestyle selection  which negatively influence male fertility:

• Smoke decreases sperm viability and mobility both quality and quantity.

• Substance abuse with long term usage of recreational drugs and  marijuana .

• alcohol abuse.

• Steroid anabolic being use  effect  shrinkage and infertility of testicular.

•Excessive  Intense exercise: which manufacture  increase levels of l steroid adrenal  hormones which affect the testosterone lack occurrence in infertility.

•Lack of  Zinc and vitamin C in the diet.

• Excess stress

• Underwear that are tight increases temperature  of scrotal  as a results in reduction of sperm production.

• Anemia and malnutrition. 

Behavioral improvement lead to improvement in  man’s fertility and couple 

Male  risk factors of infertility are:

     An enlarged varicose vein called Variocele in the spermatic cord which connects to testicle

At old age, this reduces sperm counts and decreases the genetic standard of sperm and its mobility

Sexual related diseases, that causes fear in male reproductive system or render sperm function inactive include

Lifestyle attitude which are substance abuse and smoking

Intensive exposure at long-term rate   to specific types of chemicals, medications or toxins.

Diagnosis

     Apart from the physical exam and medical history, essential tests towards male infertility include:

Imaging tests towards looking at structural problems

Blood testing to ascertain hormone levels

Analysis of semen in evaluating quantity and the quality of sperm

 Genetically testing to ascertain sperm DNA fragmentation genetic diseases and chromosomal defects

Treatment

     Male infertility treatment must first notice underlying medical problems that are contributing towards fertility problems. Therapeutic method of drug use may be applied in the treatment of hormonal malfunctioning. Surgical operation can be applied towards correcting any obstructions at reproductive tract and variocele.

When infertility problem remain unsolved, intracytoplasmic sperm injection (ICSI) is commonly applied combined with vitro fertilization (IVF) to get pregnant if male infertility are one of the factor. The ICSI include given injection to  a single sperm inside an egg obtained from IVF. Fertilized egg then implanted into woman. Successes   of pregnant progress depend on various attributing factors.

Infertility. So many treatment opportunity are  available for proper management, in some cases treatment will not be effective.  In some instances, man infertility caused by damage to resulting inefficient of the sperm production due to failure of testicle that if damage sperm will not be able to produce sperm efficiently, this is the same as menopause reach by women naturally which cannot be treated. Inspite availability of medical drug which hinder capability to manage infertility in man,many management and treatment availability  for many causes. Outside damage to testicule, main cause of male infertility are poor sperm quality and low sperm count.

Bromocriptine or Cabergoline

Bromocriptine and cabergoline are pills taken orally to treat strangely abnormal amounts of the hormone prolactin, which can stop ovulation.2 Certain meds, kidney infection, and thyroid sickness can bring about elevated amounts of prolactin.

Bromocriptine or cabergoline permit 90% of ladies to have ordinary prolactin levels.1 When prolactin levels get to be ordinary, 85% of ladies utilizing